Jason Bourne's nemesis Arkadin is still hot on his trail and the two continue their struggle, reversing roles of hunter and hunted. When Bourne is ambushed and badly wounded, he fakes his death and goes into hiding. In safety, he takes on a new identity, and begins a mission to find out who tried to assassinate him.

Meanwhile, an American passenger airliner is shot down. Bourne's search for the man who shot him intersects with the search for the people that brought down the airliner, leading him into one of the most deadly and challenging situations he has ever encountered.

With the threat of a new world war brewing, Bourne finds himself in a race against time to uncover the truth and find the person behind his assault, all the while being stalked by his unknown nemesis...